Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651041 | 0.85 | EP300 (0.45) | LMNAABCB11PTGS1EP300MEN1 | |
| SCHEMBL7658829 | 0.81 | EP300 (0.53) | LMNAABCB11PTGS1EP300MEN1 | |
| SCHEMBL7660452 | 0.76 | CCKBR (0.39) | LMNAABCB11PTGS1EP300MAPT | |
| SCHEMBL11375845 | 0.74 | EP300 (0.50) | EP300MEN1KMT2AMAPTPOLB | |
| SCHEMBL11375289 | 0.71 | EP300 (0.50) | EP300MEN1KMT2AHPGDPOLB | |
| SCHEMBL7655852 | 0.69 | EP300 (0.46) | LMNAEP300MEN1KMT2AHPGD | |
| SCHEMBL7658228 | 0.68 | EP300 (0.50) | EP300MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL7657008 | 0.67 | EP300 (0.68) | LMNAEP300MEN1KMT2AHPGD | |
| SCHEMBL10517143 | 0.66 | MAPT (0.52) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL7665570 | 0.66 | MAPT (0.39) | MEN1KMT2AHPGDMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064269-A1 | BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME | Hoechst Marion Roussel (FR) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999050252-A2 | BARBITURIC ACID DERIVATIVE AND PREVENTIVE AND THERAPEUTIC AGENT FOR BONE AND CARTILAGE CONTAINING THE SAME | HOECHST MARION ROUSSEL (FR) | 1999-10-07 | — | — | WO | disclosed |