Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3035597 | 0.86 | USP2 (0.45) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL23481174 | 0.79 | HRH3 (0.43) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL4689251 | 0.77 | GPR119 (0.49) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL31189134 | 0.77 | USP2 (0.47) | USP2SMN1; SMN2GPR119RECQLALOX15 | |
| SCHEMBL23459268 | 0.77 | USP2 (0.40) | USP2SMN1; SMN2GPR119RECQLDDB1 | |
| SCHEMBL23459382 | 0.77 | SSTR5 (0.43) | GPR119MAPTUSP30HRH3 | |
| SCHEMBL3494873 | 0.76 | SMN1; SMN2 (0.41) | USP2SMN1; SMN2GPR119RECQLKDM4E | |
| SCHEMBL23484356 | 0.76 | NR1H2 (0.46) | USP2SMN1; SMN2GPR119DDB1CRBN | |
| SCHEMBL17760283 | 0.76 | KCNJ1 (0.46) | USP2SMN1; SMN2GPR119KDM4EMAPT | |
| SCHEMBL1086688 | 0.76 | OPRD1 (0.50) | GPR119USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087770-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-1087770-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| US-6172076-B1 | HETEROCYCLE-SUBSTITUTED 1,3,8-TRIAZASPIRO(4,5)DECANE DERIVATIVES; TREATING ARTERIOSCLEROSIS | MERCK & CO., INC. | 2001-01-09 | — | — | US | disclosed |
| WO-1999065494-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-12-23 | — | — | WO | disclosed |