Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | ANPEP | P15144 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 1/20 | 0.32 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.32 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837998 | 0.85 | MMP1 (0.37) | ADAM17APPMMP2MMP9MMP1 | |
| SCHEMBL6946529 | 0.85 | ADAM17 (0.40) | ADAM17TGFBR1MEN1KMT2AAPP | |
| SCHEMBL6946530 | 0.85 | ADAM17 (0.40) | ADAM17TGFBR1MEN1KMT2AAPP | |
| SCHEMBL7960563 | 0.84 | ADAM17 (0.39) | ADAM17TGFBR1MEN1KMT2AAPP | |
| SCHEMBL7839914 | 0.84 | ADAM17 (0.39) | ADAM17TGFBR1MEN1KMT2AAPP | |
| SCHEMBL7835569 | 0.84 | ADAM17 (0.39) | ADAM17TGFBR1MEN1KMT2AAPP | |
| SCHEMBL7840733 | 0.84 | ADAM17 (0.37) | ADAM17TGFBR1MEN1KMT2AAPP | |
| SCHEMBL7840735 | 0.84 | ADAM17 (0.37) | ADAM17TGFBR1MEN1KMT2AAPP | |
| SCHEMBL7955132 | 0.84 | ADAM17 (0.44) | ADAM17TGFBR1ALDH1A1APPMMP2 | |
| SCHEMBL7835552 | 0.84 | ADAM17 (0.44) | ADAM17TGFBR1ALDH1A1APPMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |