Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 4/20 | 0.31 |
| ▸ | MMP2 | P08253 | 3/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839914 | 1.00 | ADAM17 (0.39) | ADAM17TGFBR1APPMEN1KMT2A | |
| SCHEMBL7955132 | 0.85 | ADAM17 (0.44) | ADAM17TGFBR1APPCASP1CASP3 | |
| SCHEMBL7835552 | 0.85 | ADAM17 (0.44) | ADAM17TGFBR1APPCASP1CASP3 | |
| SCHEMBL7828157 | 0.85 | ADAM17 (0.39) | ADAM17TGFBR1APPMEN1KMT2A | |
| SCHEMBL6946530 | 0.85 | ADAM17 (0.40) | ADAM17TGFBR1APPMEN1KMT2A | |
| SCHEMBL6946529 | 0.85 | ADAM17 (0.40) | ADAM17TGFBR1APPMEN1KMT2A | |
| SCHEMBL7840552 | 0.84 | ADAM17 (0.37) | ADAM17TGFBR1APPMEN1KMT2A | |
| SCHEMBL7957347 | 0.84 | ADAM17 (0.38) | ADAM17TGFBR1APPP2RX3MMP9 | |
| SCHEMBL7957348 | 0.84 | ADAM17 (0.38) | ADAM17TGFBR1APPP2RX3MMP9 | |
| SCHEMBL7837114 | 0.84 | ADAM17 (0.37) | ADAM17TGFBR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |