SCHEMBL7840872

SCHEMBL7840872

O=C(O)Oc1cn(CCF)c2c(Cl)c(Cl)ncc2c1=O

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
CNR2 P34972 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7848888 0.87 LMNA (0.35) KDM4E
SCHEMBL7840720 0.85 TNF (0.33) KDM4E
SCHEMBL7840869 0.84 KDM4E (0.47) KDM4E
SCHEMBL8697711 0.78 POLB (0.44) KDM4E
SCHEMBL7851036 0.76 ALDH1A1 (0.37) KDM4E
SCHEMBL7850889 0.76 LMNA (0.34) KDM4E
SCHEMBL7849791 0.76 CYP3A4 (0.31)
SCHEMBL7849352 0.75
SCHEMBL7841811 0.74 TDP1 (0.37)
SCHEMBL7851435 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0726270-A1 Derivatives of 1,6-naphthyridine carboxylic acids BAYER AG (DE) 1996-08-14 EP claimed
EP-0726270-B1 Derivatives of 1,6-naphthyridone carboxylic acids BAYER AG (DE) 2001-05-23 EP disclosed
EP-0726270-A1 Derivatives of 1,6-naphthyridine carboxylic acids BAYER AG (DE) 1996-08-14 EP disclosed