Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | TYMS | P04818 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841811 | 0.90 | TDP1 (0.37) | TNFCUL4APOLBLMNAMEN1 | |
| SCHEMBL7840872 | 0.85 | KDM4E (0.34) | KDM4E | |
| SCHEMBL8697711 | 0.85 | POLB (0.44) | KDM4EPOLBLMNAMEN1ALDH1A1 | |
| SCHEMBL7840741 | 0.80 | ADRB2 (0.34) | TNFCUL4APOLBMEN1ALDH1A1 | |
| SCHEMBL7851893 | 0.80 | CYP3A4 (0.31) | CUL4A | |
| SCHEMBL7849978 | 0.80 | GABRA2 (0.39) | POLBLMNAMEN1MAPTHTT | |
| SCHEMBL7849137 | 0.79 | KDM4E (0.33) | CUL4AKDM4ELMNAALDH1A1RAB9A | |
| SCHEMBL7848888 | 0.78 | LMNA (0.35) | KDM4EPOLBLMNAMEN1ALDH1A1 | |
| SCHEMBL7840723 | 0.77 | ATP4A (0.37) | TNFKDM4ELMNAMEN1ALDH1A1 | |
| SCHEMBL7840869 | 0.77 | KDM4E (0.47) | KDM4ELMNAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |