Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30791548 | 0.83 | PYGL (0.65) | PYGLGRIN1GRIN2BTRPV1ALDH1A1 | |
| SCHEMBL28190396 | 0.83 | PYGL (0.65) | PYGLGRIN1GRIN2BTRPV1ALDH1A1 | |
| SCHEMBL78604 | 0.79 | TSHR (0.38) | LMNAMAPTRAF1BRAFALDH1A1 | |
| SCHEMBL91334 | 0.79 | PYGL (0.49) | GAAPYGLKMT2AGRIN1GRIN2B | |
| SCHEMBL7248605 | 0.78 | GAA (0.74) | GAAKMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL1750889 | 0.78 | PYGL (0.48) | PYGLKMT2AGRIN1GRIN2BTRPV1 | |
| SCHEMBL1750381 | 0.77 | PYGL (0.47) | PYGLKMT2AGRIN1GRIN2BTRPV1 | |
| SCHEMBL30729428 | 0.75 | ALDH1A1 (0.48) | PYGLKMT2AMAPTGRIN1GRIN2B | |
| SCHEMBL14387746 | 0.75 | HDAC1 (0.53) | MAPTALDH1A1 | |
| SCHEMBL12993168 | 0.74 | CYP2C19 (0.56) | GAATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |