Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.41 |
| ▸ | PCNA | P12004 | 1/20 | 0.40 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750889 | 0.89 | PYGL (0.48) | PYGLKMT2AGRIN1GRIN2BPCNA | |
| SCHEMBL28190396 | 0.85 | PYGL (0.65) | PYGLGRIN1GRIN2BFFAR1TRPV1 | |
| SCHEMBL30791548 | 0.85 | PYGL (0.65) | PYGLGRIN1GRIN2BFFAR1TRPV1 | |
| SCHEMBL1751125 | 0.81 | KMT2A (0.41) | PYGLKMT2AGRIN1GRIN2BPCNA | |
| SCHEMBL44421 | 0.81 | ALDH1A1 (0.44) | PYGLKMT2AFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2635483 | 0.79 | KMT2A (0.40) | PYGLKMT2AGRIN1GRIN2BPCNA | |
| SCHEMBL2635482 | 0.79 | KMT2A (0.47) | PYGLKMT2AALDH1A1GAA | |
| SCHEMBL1750381 | 0.79 | PYGL (0.47) | PYGLKMT2AGRIN1GRIN2BPCNA | |
| SCHEMBL78415 | 0.79 | GAA (0.48) | PYGLKMT2AGRIN1GRIN2BTRPV1 | |
| SCHEMBL91284 | 0.78 | TSHR (0.43) | AKT1ALDH1A1L3MBTL1KCNH2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |