Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | YWHAG | P61981 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91284 | 0.81 | TSHR (0.43) | TSHRSMN1; SMN2KDM4EALDH1A1REN | |
| SCHEMBL78415 | 0.79 | GAA (0.48) | LMNAALDH1A1MAPTRAF1BRAF | |
| SCHEMBL78606 | 0.76 | IDO1 (0.39) | TSHRLMNAALDH1A1MAPK1MAPT | |
| SCHEMBL10885864 | 0.74 | CYP1A2 (0.50) | SMN1; SMN2KDM4EALDH1A1CYP2D6 | |
| SCHEMBL1751401 | 0.73 | REN (0.43) | TSHRSMN1; SMN2KDM4ERENCHRM5 | |
| SCHEMBL11650876 | 0.71 | NPC1 (0.53) | SMN1; SMN2KDM4EMAPT | |
| SCHEMBL20234272 | 0.71 | CHRM2 (0.43) | SMN1; SMN2LMNACHRM2CHRM4CHRM5 | |
| SCHEMBL1751233 | 0.71 | REN (0.51) | REN | |
| SCHEMBL78610 | 0.71 | LMNA (0.43) | SMN1; SMN2LMNAKDM4ERENMAPK1 | |
| SCHEMBL4682925 | 0.70 | REN (0.56) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |