Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.47 |
| ▸ | KDM5C | P41229 | 6/20 | 0.47 |
| ▸ | KDM5A | P29375 | 5/20 | 0.47 |
| ▸ | KDM6B | O15054 | 4/20 | 0.47 |
| ▸ | KDM4A | O75164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.47 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.47 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.47 |
| ▸ | TET3 | O43151 | 1/20 | 0.47 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7838365 | 0.83 | KDM4C (0.50) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL18765053 | 0.80 | KDM4C (0.50) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL1647272 | 0.78 | CYP1A2 (0.61) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL17820831 | 0.77 | KDM4C (0.53) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL7670706 | 0.75 | KDM4C (0.57) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL2305108 | 0.75 | KDM4C (0.57) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL16055756 | 0.75 | KDM4E (0.65) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL28162381 | 0.75 | KDM4C (0.52) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL31191238 | 0.74 | KDM4C (0.55) | KDM4CKDM5BKDM5CKDM5AKDM6B | |
| SCHEMBL12252467 | 0.74 | GABRP (0.58) | KDM4CKDM5BKDM5CKDM5AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |