Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.58 |
| ▸ | GABRD | O14764 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.58 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.58 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.58 |
| ▸ | GABRE | P78334 | 1/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.58 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.58 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.58 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.58 |
| ▸ | KDM5C | P41229 | 7/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.55 |
| ▸ | KDM6B | O15054 | 5/20 | 0.55 |
| ▸ | KDM4A | O75164 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1244313 | 0.98 | GABRP (0.56) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL509023 | 0.85 | CYP1A2 (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2305108 | 0.82 | KDM4C (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7670706 | 0.82 | KDM4C (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL31191238 | 0.81 | KDM4C (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL30560163 | 0.81 | KDM4C (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL845767 | 0.81 | KDM4C (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1647272 | 0.81 | CYP1A2 (0.61) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28331934 | 0.81 | KDM4C (0.55) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL4450004 | 0.79 | KDM4E (0.55) | KDM5CKDM4CKDM6BKDM4EKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| US-9024022-B2 | Substrates of O6-alkylguanine-DNA alkyltransferase and mutants thereof | CIS BIO INTERNATIONAL (FR) | 2015-05-05 | — | — | US | disclosed |
| US-9024022-B2 | Substrates of O6-alkylguanine-DNA alkyltransferase and mutants thereof | CIS BIO INTERNATIONAL (FR) | 2015-05-05 | — | — | US | disclosed |
| EP-2331510-B1 | SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE (AGT) AND THEIR USE IN METHOD OF LABELLING | ION BEAM APPLIC SA (BE) | 2013-11-06 | — | — | EP | disclosed |
| US-20110236952-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | CIS BIO INTERNATIONAL (FR) | 2011-09-29 | — | — | US | disclosed |
| US-20110236952-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | CIS BIO INTERNATIONAL (FR) | 2011-09-29 | — | — | US | disclosed |
| WO-2010034931-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | CIS-BIO INTERNATIONAL (FR) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110236952-A1 | NOVEL SUBSTRATES OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE AND MUTANTS THEREOF | OGG1, UNG, MPG | GABRP 4121/4885GABRD 4367/4885GABRA1 4369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.