Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 11/20 | 0.66 |
| ▸ | BACE1 | P56817 | 11/20 | 0.66 |
| ▸ | BCHE | P06276 | 8/20 | 0.66 |
| ▸ | VCP | P55072 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.57 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.57 |
| ▸ | FABP6 | P51161 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13573605 | 0.91 | ACHE (0.55) | ACHEBACE1BCHEVCPMEN1 | |
| SCHEMBL8355347 | 0.89 | ACHE (0.57) | ACHEBACE1BCHEVCPMEN1 | |
| SCHEMBL22815725 | 0.89 | ACHE (0.70) | ACHEBACE1BCHEVCPMEN1 | |
| SCHEMBL7837850 | 0.89 | VCP (0.60) | ACHEBACE1BCHEVCPMEN1 | |
| SCHEMBL7839245 | 0.85 | VCP (0.59) | ACHEBACE1BCHEVCPMEN1 | |
| SCHEMBL3958384 | 0.85 | DRD4 (0.56) | ACHEBACE1BCHEVCPMEN1 | |
| SCHEMBL7844261 | 0.83 | VCP (0.60) | ACHEBACE1BCHEVCPGRIN2B | |
| SCHEMBL663239 | 0.81 | GRIN2B (0.74) | ACHEBACE1BCHEMEN1KMT2A | |
| SCHEMBL13798544 | 0.81 | CHRNA7 (0.50) | ACHEBACE1BCHEVCPMEN1 | |
| SCHEMBL8081164 | 0.81 | ACHE (0.68) | ACHEBACE1BCHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1705670-A | 2, 3-dihydro-6-nitroimidazo [2, 1-b ] oxazole compounds | OTSUKA PHARMA CO LTD (JP) | 2005-12-07 | — | — | CN | disclosed |
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |