Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | ME3 | Q16798 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7897978 | 0.90 | ME3 (0.62) | VCPGRIN2BTAAR1DRD4SIGMAR1 | |
| SCHEMBL7902701 | 0.85 | FOXM1 (0.53) | VCPGRIN2BTAAR1DRD4ME3 | |
| SCHEMBL7841536 | 0.83 | ACHE (0.66) | VCPGRIN2BBCHEACHEBACE1 | |
| SCHEMBL662411 | 0.82 | GRIN2B (0.76) | GRIN2BTAAR1OPRM1OPRL1SIGMAR1 | |
| SCHEMBL24123852 | 0.82 | ME3 (0.46) | VCPHTR1AME3BCHEACHE | |
| SCHEMBL22878525 | 0.82 | GRIN2B (0.66) | VCPGRIN2BTAAR1DRD4OPRM1 | |
| SCHEMBL17284578 | 0.82 | GRIN2B (0.61) | VCPGRIN2BTAAR1DRD4OPRM1 | |
| SCHEMBL4218912 | 0.82 | GRIN2B (0.66) | GRIN2BTAAR1DRD4OPRM1OPRL1 | |
| SCHEMBL7899005 | 0.82 | ME3 (0.60) | GRIN2BDRD4SIGMAR1GRIN1ME3 | |
| SCHEMBL7467264 | 0.81 | ACHE (0.71) | GRIN2BSIGMAR1HTR5ABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |