Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7196401 | 0.84 | TDP1 (0.58) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL18379331 | 0.79 | CDK4 (0.54) | HTTTSHRRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL3389268 | 0.75 | TDP1 (0.48) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL1136897 | 0.73 | TDP1 (0.43) | TDP1HTTTSHRPOLBL3MBTL1 | |
| SCHEMBL4160135 | 0.71 | TDP1 (0.42) | AGERTDP1HTTTSHRPOLB | |
| SCHEMBL9903762 | 0.69 | FGFR1 (0.58) | TDP1HTTPOLBRAB9AL3MBTL1 | |
| SCHEMBL4553023 | 0.68 | TDP1 (0.46) | TDP1HTTTSHRPOLBTNF | |
| SCHEMBL7018098 | 0.68 | TDP1 (0.42) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL29001215 | 0.67 | CDK4 (0.46) | HTTTSHRRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL369486 | 0.67 | TDP1 (0.41) | TDP1HTTTSHRPOLBTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |
| US-5886008-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-03-23 | — | — | US | disclosed |