Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 6/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840900 | 0.87 | TOP2A (0.37) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL7850179 | 0.87 | CYP3A4 (0.31) | CUL4ATYMS | |
| SCHEMBL7840741 | 0.83 | ADRB2 (0.34) | ADRB2TOP2ATOP2BTNFKCNH2 | |
| SCHEMBL8696129 | 0.83 | ADRB2 (0.44) | ADRB2TOP2ATOP2BALDH1A1POLB | |
| SCHEMBL7503528 | 0.78 | ADRB2 (0.40) | ADRB2TOP2ATOP2BKCNH2 | |
| SCHEMBL9687476 | 0.77 | CUL4A (0.36) | ADRB2TOP2ATOP2BTNFCUL4A | |
| SCHEMBL7840898 | 0.77 | TOP2A (0.52) | TOP2ATOP2BKCNH2ALDH1A1POLB | |
| SCHEMBL7817401 | 0.76 | ADRB2 (0.47) | ADRB2TOP2ATOP2BKCNH2ALDH1A1 | |
| SCHEMBL9416462 | 0.76 | TNF (0.35) | TNFMAPTALDH1A1POLB | |
| SCHEMBL7095727 | 0.76 | DPP4 (0.40) | ADRB2TOP2ATOP2BKCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726270-B1 | Derivatives of 1,6-naphthyridone carboxylic acids | BAYER AG (DE) | 2001-05-23 | — | — | EP | disclosed |
| EP-0726270-A1 | Derivatives of 1,6-naphthyridine carboxylic acids | BAYER AG (DE) | 1996-08-14 | — | — | EP | disclosed |