Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839766 | 0.87 | ADRA1B (0.54) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| SCHEMBL7839287 | 0.85 | ADRA1D (0.50) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| SCHEMBL7842970 | 0.83 | MAPT (0.47) | ADRA1DHTR1ADRD2DRD4DRD3 | |
| SCHEMBL7844493 | 0.82 | DRD2 (0.52) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| SCHEMBL7838368 | 0.81 | HTR1A (0.55) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL8041535 | 0.81 | DRD2 (0.51) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL8043712 | 0.81 | HTR1A (0.55) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| SCHEMBL7838517 | 0.77 | DRD2 (0.57) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| SCHEMBL7829445 | 0.77 | DRD2 (0.55) | ADRA1AADRA1BADRA1DHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL8039750 | 0.77 | DRD2 (0.54) | ADRA1AADRA1BADRA1DHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839144-B1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL GMBH (DE) | 2001-09-19 | — | — | EP | claimed |
| EP-0839144-A1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1998-05-06 | — | — | EP | claimed |
| WO-1997003067-A1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-30 | — | — | WO | claimed |
| US-6114334-A | CENTRAL NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-09-05 | — | — | US | disclosed |
| EP-0839144-A1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997003067-A1 | PIPERAZINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-30 | — | — | WO | disclosed |