Methanesulfonamide

SCHEMBL7843333

CC1(C)Cc2c(-c3ccccc3)c(-c3ccc(C(F)(F)F)cc3)c(CC(=O)O)n2C1.CS(N)(=O)=O

nearest known ligand 0.73

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	ALOX5	P09917	4/20	0.67

▸	PTGS1	P23219	4/20	0.67

▸	PTGES	O14684	2/20	0.67

▸	ALOX5AP	P20292	1/20	0.67

▸	PTGS2	P35354	1/20	0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL9458992	0.84	ALOX5 (0.86)	ALOX5PTGS1PTGESALOX5APPTGS2
SCHEMBL12203023	0.81	ALOX5 (0.81)	ALOX5PTGS1PTGESALOX5APPTGS2
Licofelone SCHEMBL237833	0.80	ALOX5 (1.00)	ALOX5PTGS1PTGESALOX5APPTGS2
Licofelone SCHEMBL1394262	0.78	PTGES (0.84)	ALOX5PTGS1PTGESALOX5APPTGS2
Licofelone SCHEMBL1843506	0.77	PTGES (0.92)	ALOX5PTGS1PTGESALOX5APPTGS2
Licofelone SCHEMBL7737421	0.75	PTGES (0.88)	ALOX5PTGS1PTGESALOX5APPTGS2
SCHEMBL4087247	0.74	PTGES (0.83)	ALOX5PTGS1PTGESALOX5APPTGS2
SCHEMBL13697422	0.73	PTGES (0.85)	ALOX5PTGS1PTGESALOX5APPTGS2
SCHEMBL5560426	0.73	PTGES (0.85)	ALOX5PTGS1PTGESALOX5APPTGS2
SCHEMBL19499839	0.73	PTGES (0.85)	ALOX5PTGS1PTGESALOX5APPTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0763037-B1	[a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF	MERCKLE GMBH (DE)	2001-11-14	—	—	EP	claimed
US-5942535-A	a!-Annelated pyrrole derivatives and pharmaceutical use thereof	MERCKLE GMBH (DE)	1999-08-24	—	—	US	claimed