SCHEMBL7843357

SCHEMBL7843357

CC(=O)Nc1cc(OCc2ccc(Cl)cc2)ccc1-c1c(C(F)(F)F)n(C)c(=O)[nH]c1=O

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAOB P27338 14/20 0.47
MAOA P21397 8/20 0.40
DRD1 P21728 1/20 0.38
AR P10275 1/20 0.37
BRD4 O60885 1/20 0.35
PLAT P00750 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7854098 0.90 NPC1 (0.40) MAOBMAOADRD1
SCHEMBL7851719 0.84 MAOB (0.52) MAOBMAOAARPLAT
SCHEMBL7849461 0.81 MAOB (0.48) MAOBMAOAAR
SCHEMBL8489930 0.74 MAOB (0.48) MAOBMAOA
SCHEMBL8087595 0.74 MAOB (0.45) MAOBMAOADRD1PLAT
SCHEMBL7610769 0.72 MAOB (0.41) MAOBMAOAARBRD4
SCHEMBL7851641 0.71 MAOB (0.38) MAOB
SCHEMBL31451933 0.66 MAOA (0.57) MAOBMAOABRD4
SCHEMBL10934447 0.64 ALDH1A1 (0.52) MAOBMAOA
SCHEMBL10597979 0.64 KMT2A (0.66) MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066267-A1 SUBSTITUTED PHENYL URACILS Bayer Aktiengesellschaft (DE) 2001-01-10 EP disclosed
WO-1999028302-A1 SUBSTITUTED PHENYL URACILS BAYER AKTIENGESELLSCHAFT (DE) 1999-06-10 WO disclosed