Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29628588 | 0.81 | NOTUM (0.39) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL9189008 | 0.78 | GAA (0.49) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL29503805 | 0.77 | SMN1; SMN2 (0.51) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL30027448 | 0.77 | MAPT (0.37) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL9680967 | 0.76 | NOTUM (0.42) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL14125002 | 0.72 | NOTUM (0.56) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL8522694 | 0.70 | ALDH1A1 (0.42) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL9188823 | 0.69 | NOTUM (0.60) | NOTUMSMN1; SMN2EPHX2RAB9ACYP1A2 | |
| SCHEMBL24977286 | 0.68 | EPHX2 (0.41) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL9189318 | 0.67 | NOTUM (1.00) | NOTUMALDH1A1GAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | claimed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | claimed |