Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
| ▸ | FAP | Q12884 | 2/20 | 0.54 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564104 | 0.82 | EPHX2 (0.53) | EPHX2FAPKDM4EALDH1A1MAPK1 | |
| SCHEMBL7852927 | 0.81 | FAP (0.54) | FAPKDM4EL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL7852243 | 0.80 | FAP (0.49) | EPHX2FAPALDH1A1ACKR3 | |
| SCHEMBL3168169 | 0.79 | DGAT1 (0.58) | EPHX2L3MBTL1ALDH1A1DGAT1 | |
| SCHEMBL3168186 | 0.79 | DGAT1 (0.58) | EPHX2L3MBTL1ALDH1A1DGAT1 | |
| SCHEMBL4924225 | 0.78 | L3MBTL1 (0.50) | EPHX2GRM5L3MBTL1DGAT1 | |
| SCHEMBL4924222 | 0.78 | L3MBTL1 (0.50) | EPHX2GRM5L3MBTL1DGAT1 | |
| SCHEMBL4927632 | 0.78 | L3MBTL1 (0.53) | EPHX2GRM5L3MBTL1DGAT1 | |
| SCHEMBL3175587 | 0.78 | DGAT1 (0.54) | EPHX2GRM5L3MBTL1ALDH1A1TSHR | |
| SCHEMBL3178325 | 0.78 | DGAT1 (0.54) | EPHX2GRM5L3MBTL1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |