Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 8/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.33 |
| ▸ | SMO | Q99835 | 4/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 3/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843836 | 1.00 | HRH2 (0.33) | HRH2HRH4SMOITGB3ITGB1 | |
| SCHEMBL7236710 | 0.92 | NPFFR1 (0.34) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7846044 | 0.85 | ITGB3 (0.34) | HRH2HRH4ITGB3ITGB1ITGAV | |
| SCHEMBL7846035 | 0.85 | ITGB3 (0.34) | HRH2HRH4ITGB3ITGB1ITGAV | |
| SCHEMBL7237049 | 0.77 | NPFFR1 (0.36) | ITGB3ITGB1ITGAVITGA2BITGB5 | |
| SCHEMBL7843840 | 0.76 | HRH2 (0.34) | HRH2HRH4SMOITGB3ITGB1 | |
| SCHEMBL7228914 | 0.74 | SIGMAR1 (0.41) | HRH2HRH4SMOITGB3ITGB1 | |
| SCHEMBL7846039 | 0.73 | HRH2 (0.36) | HRH2HRH4ITGB3ITGB1ITGAV | |
| SCHEMBL7240547 | 0.72 | HRH2 (0.43) | HRH2HRH4ITGB3ITGB1ITGAV | |
| SCHEMBL7240551 | 0.72 | HRH2 (0.43) | HRH2HRH4ITGB3ITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157022-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049015-A1 | PYRIDINE COMPOUNDS AND THEIR PHARMACEUTICAL USE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-08-24 | — | — | WO | disclosed |