Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | PTPRA | P18433 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846486 | 0.85 | GPR84 (0.50) | BLMNPSR1PTPRASCN9ACYP2C19 | |
| SCHEMBL7997830 | 0.79 | HTR2A (0.53) | BLMNPSR1CYP2C19LMNATSHR | |
| SCHEMBL30381776 | 0.78 | KMT2A (0.66) | CHRNB2CHRNA7CHRNA4BLMNPSR1 | |
| SCHEMBL274624 | 0.78 | KMT2A (0.66) | CHRNB2CHRNA7CHRNA4BLMNPSR1 | |
| SCHEMBL29855626 | 0.78 | KMT2A (0.66) | CHRNB2CHRNA7CHRNA4BLMNPSR1 | |
| SCHEMBL8502601 | 0.78 | KMT2A (0.66) | CHRNB2CHRNA7CHRNA4BLMNPSR1 | |
| SCHEMBL274625 | 0.78 | KMT2A (0.66) | CHRNB2CHRNA7CHRNA4BLMNPSR1 | |
| SCHEMBL8525797 | 0.78 | TACR1 (0.51) | CHRNB2CHRNA7CHRNA4BLMNPSR1 | |
| SCHEMBL16976220 | 0.77 | PTPRA (0.51) | CHRNB2CHRNA7CHRNA4BLMNPSR1 | |
| SCHEMBL19846983 | 0.77 | PTPRA (0.51) | CHRNB2CHRNA7CHRNA4BLMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |