Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | SOS1 | Q07889 | 5/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | PTPRA | P18433 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843940 | 0.85 | CHRNB2 (0.43) | HTR2ASOS1ADRB3BLMPTPRA | |
| SCHEMBL7993961 | 0.79 | HTR2A (0.53) | GPR84HTR2ASLC6A4MPOTSHR | |
| SCHEMBL29405769 | 0.78 | KMT2A (0.66) | GPR84HTR2ASOS1BLMPTPRA | |
| SCHEMBL10958198 | 0.78 | SCN9A (0.59) | GPR84HTR2ASOS1ADRB3BLM | |
| SCHEMBL128685 | 0.78 | KMT2A (0.66) | GPR84HTR2ASOS1BLMPTPRA | |
| SCHEMBL456668 | 0.78 | KMT2A (0.66) | GPR84HTR2ASOS1BLMPTPRA | |
| SCHEMBL30381542 | 0.78 | KMT2A (0.66) | GPR84HTR2ASOS1BLMPTPRA | |
| SCHEMBL18029175 | 0.78 | KMT2A (0.66) | GPR84HTR2ASOS1BLMPTPRA | |
| SCHEMBL623336 | 0.78 | KMT2A (0.66) | GPR84HTR2ASOS1BLMPTPRA | |
| SCHEMBL15313351 | 0.78 | SOS1 (0.53) | GPR84HTR2ASOS1NR4A2BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |