Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.46 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | HTR1B | P28222 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR5A | P47898 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | HTR1E | P28566 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7993961 | 0.86 | HTR2A (0.53) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| SCHEMBL8001659 | 0.86 | MPO (0.62) | HTR2ATRPM8MTNR1AMTNR1BHTR1A | |
| SCHEMBL7983652 | 0.81 | SLC6A4 (0.41) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| SCHEMBL7843940 | 0.79 | CHRNB2 (0.43) | HTR2AHTR1ASLC6A4HTR7HTR1B | |
| SCHEMBL8001578 | 0.77 | HTR2A (0.57) | HTR2ATRPM8MTNR1AMTNR1BHTR1A | |
| SCHEMBL7995675 | 0.77 | HTR2A (0.57) | HTR2ATRPM8MTNR1AMTNR1BHTR1A | |
| SCHEMBL7997990 | 0.77 | HTR2A (0.57) | HTR2ATRPM8MTNR1AMTNR1BHTR1A | |
| SCHEMBL7997361 | 0.77 | HTR2A (0.41) | HTR2AMTNR1AMTNR1BHTR2CTDP1 | |
| SCHEMBL7998303 | 0.76 | HTR1D (0.47) | HTR2AMTNR1AMTNR1BHTR1AHTR1B | |
| SCHEMBL7984083 | 0.76 | HTR2B (0.52) | HTR2ATRPM8MTNR1AMTNR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001040183-A1 | 1-AMINOALKYL-1H-INDOLES FOR TREATING GLAUCOMA | ALCON UNIVERSAL LTD. (CH) | 2001-06-07 | — | — | WO | disclosed |