Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854121 | 0.94 | NPC1 (0.51) | KMT2ANPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL7843759 | 0.85 | NPC1 (0.45) | KMT2ANPC1RAB9AALDH1A1EPHX2 | |
| SCHEMBL7851487 | 0.82 | SIGMAR1 (0.48) | ALDH1A1KDM4ETDP1EPHX2ACE2 | |
| SCHEMBL7855242 | 0.82 | KDM4E (0.63) | KMT2ARAB9AALDH1A1KDM4ETDP1 | |
| SCHEMBL7851592 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4EACE2 | |
| SCHEMBL7852935 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KDM4ETDP1EPHX2ACE2 | |
| SCHEMBL7846923 | 0.81 | ACE (0.51) | ALDH1A1KDM4EACE2 | |
| SCHEMBL7853918 | 0.81 | CTSL (0.48) | KMT2AALDH1A1KDM4ETDP1EPHX2 | |
| SCHEMBL7853586 | 0.81 | ALDH1A1 (0.49) | KMT2AALDH1A1KDM4ETDP1EPHX2 | |
| SCHEMBL7845476 | 0.80 | ALDH1A1 (0.50) | KMT2ANPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |