Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829901 | 0.86 | BCAT2 (0.40) | BCAT2PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL7841948 | 0.86 | BCAT2 (0.44) | BCAT2PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL7844135 | 0.80 | PTGS2 (0.57) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL6250243 | 0.78 | BCAT2 (0.50) | BCAT2PTGS2AKR1C2AKR1C1LMNA | |
| SCHEMBL8002389 | 0.78 | BCAT2 (0.50) | BCAT2PTGS2AKR1C2AKR1C1LMNA | |
| SCHEMBL7840110 | 0.73 | BCAT2 (0.40) | BCAT2PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL8388365 | 0.71 | ESR2 (0.44) | BCAT2PTGS2HSD11B1LMNASMN1; SMN2 | |
| SCHEMBL8092899 | 0.71 | PTGS2 (0.57) | PTGS2AKR1C2AKR1C1AKR1C3 | |
| SCHEMBL8388530 | 0.70 | ESR2 (0.40) | BCAT2PTGS2HSD11B1LMNASMN1; SMN2 | |
| SCHEMBL4475097 | 0.69 | CES2 (0.50) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828724-B1 | DIARYL-5-OXYGENATED-2-(5H)-FURANONES AS COX-2 INHIBITORS | MERCK FROSST CANADA INC (CA) | 2001-12-05 | — | — | EP | claimed |