Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ME3 | Q16798 | 2/20 | 0.60 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | ME2 | P23368 | 1/20 | 0.49 |
| ▸ | ME1 | P48163 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900897 | 0.96 | GRIN2B (0.59) | ME3GRIN2BSIGMAR1GRIN1NPC1 | |
| SCHEMBL7897978 | 0.92 | ME3 (0.62) | ME3GRIN2BSIGMAR1NPC1ALDH1A1 | |
| SCHEMBL7899612 | 0.84 | GRIN2B (0.61) | GRIN2BSIGMAR1GRIN1GAAMAPT | |
| SCHEMBL7898015 | 0.82 | KDM4E (0.54) | GRIN2BSIGMAR1GRIN1SMN1; SMN2SLC6A2 | |
| SCHEMBL7844261 | 0.82 | VCP (0.60) | ME3GRIN2BSIGMAR1GRIN1MAPT | |
| SCHEMBL7891487 | 0.81 | MCHR1 (0.47) | ME3GRIN2BNPC1ALDH1A1GAA | |
| SCHEMBL7898024 | 0.80 | ME3 (0.44) | ME3GRIN2BSIGMAR1NPC1ALDH1A1 | |
| SCHEMBL5689944 | 0.78 | GRIN2B (0.61) | GRIN2BSIGMAR1GRIN1 | |
| SCHEMBL5689946 | 0.78 | GRIN2B (0.61) | GRIN2BSIGMAR1GRIN1 | |
| SCHEMBL5690203 | 0.78 | GRIN2B (0.61) | GRIN2BSIGMAR1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | claimed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | claimed |
| US-6184236-B1 | Method of treating a neurodegenerative disease by administering an aryl-cyclohexylamine derivative | HOFFMANN-LA ROCHE INC. | 2001-02-06 | — | — | US | disclosed |
| EP-0982026-A2 | Use of aryl-cyclohexylamine derivatives in the manufacture of NMDA receptor blockers | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-01 | — | — | EP | disclosed |