Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | FAP | Q12884 | 1/20 | 0.45 |
| ▸ | FPR3 | P25089 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853086 | 0.81 | CNR1 (0.47) | CNR1NPC1SMN1; SMN2POLBFPR3 | |
| SCHEMBL7854400 | 0.77 | FAP (0.47) | FAPDPP4ALDH1A1 | |
| SCHEMBL7853026 | 0.75 | ALDH1A1 (0.44) | NPC1SMN1; SMN2FAPFPR3TSHR | |
| SCHEMBL7855306 | 0.75 | ALDH1A1 (0.58) | CNR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6443274 | 0.73 | CASP3 (0.48) | NPC1SMN1; SMN2POLBTSHRRAB9A | |
| SCHEMBL1219412 | 0.73 | ALDH1A1 (0.52) | NPC1SMN1; SMN2POLBFPR3TSHR | |
| SCHEMBL7854391 | 0.73 | NPC1 (0.47) | NPC1SMN1; SMN2POLBFAPTSHR | |
| SCHEMBL11666172 | 0.73 | CNR1 (0.67) | CNR1NPC1SMN1; SMN2POLBTSHR | |
| SCHEMBL21696581 | 0.69 | POLB (0.56) | NPC1POLBALDH1A1F2 | |
| SCHEMBL7469565 | 0.69 | ALDH1A1 (0.52) | NPC1SMN1; SMN2POLBDPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |