Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846702 | 0.73 | NOS2 (0.45) | MAPK1NOS2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL18287265 | 0.70 | NR1H2 (0.51) | NOS2SMN1; SMN2HPGDALDH1A1USP2 | |
| SCHEMBL19036910 | 0.70 | PDE4D (0.49) | PDE4DMAPK1SMN1; SMN2MEN1LMNA | |
| SCHEMBL18560018 | 0.69 | ALDH1A1 (0.46) | MAPK1SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL7845874 | 0.67 | KDM4E (0.51) | NOS2SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL16851080 | 0.67 | GAA (0.51) | PDE4DMAPK1SMN1; SMN2MEN1LMNA | |
| SCHEMBL31278120 | 0.67 | NPSR1 (0.43) | PDE4DSMN1; SMN2MEN1KMT2AHPGD | |
| SCHEMBL4233638 | 0.67 | ATM (0.45) | PDE4DSMN1; SMN2LMNAKMT2AHPGD | |
| SCHEMBL7847399 | 0.67 | TLR7 (0.48) | NOS2SMN1; SMN2MEN1LMNAKMT2A | |
| SCHEMBL7845115 | 0.66 | NOS2 (0.43) | MAPK1NOS2SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |