Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845874 | 0.74 | KDM4E (0.51) | NOS2TLR7HRH2HRH3NOS3 | |
| SCHEMBL7844689 | 0.73 | PDE4D (0.42) | NOS2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7847399 | 0.73 | TLR7 (0.48) | NOS2TLR7HRH2HRH3NOS3 | |
| SCHEMBL7845115 | 0.72 | NOS2 (0.43) | NOS2TLR7HRH2HRH3IKBKB | |
| SCHEMBL7842089 | 0.68 | MEN1 (0.46) | NOS2TLR7NOS3NOS1KDM4E | |
| SCHEMBL7845174 | 0.68 | CDK7 (0.54) | NOS2TLR7HRH2HRH3ESR1 | |
| SCHEMBL7846696 | 0.67 | RAB9A (0.62) | KDM4EALDH1A1MAPTHPGDTSHR | |
| SCHEMBL7842532 | 0.67 | NPC1 (0.62) | TLR7KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7272832 | 0.66 | NOS2 (0.44) | NOS2TLR7HRH2HRH3HRH4 | |
| SCHEMBL28792136 | 0.66 | NOS2 (0.44) | NOS2TLR7HRH2HRH3IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-5707997-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |