Dimethylformamide

Dimethylformamide

SCHEMBL7844770

CN(C)C=O.Cc1ccc2c(c1)CCC2=O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.47
CASP7 P55210 1/20 0.47
HSD17B10 Q99714 1/20 0.47
PARP10 Q53GL7 1/20 0.46
PARP11 Q9NR21 1/20 0.46
SRD5A1 P18405 2/20 0.43
HSD17B1 P14061 3/20 0.42
GRM5 P41594 1/20 0.41
METAP1 P53582 2/20 0.40
MAOB P27338 5/20 0.40
MAOA P21397 2/20 0.40
CYP1A2 P05177 1/20 0.38
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
PRKCI P41743 1/20 0.38
MIF P14174 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29726014 0.88 CASP1 (0.59) CASP1CASP7HSD17B10PARP10PARP11
SCHEMBL423287 0.88 CASP1 (0.59) CASP1CASP7HSD17B10PARP10PARP11
SCHEMBL27632859 0.88 CASP1 (0.59) CASP1CASP7HSD17B10PARP10PARP11
Hydrochloric Acid SCHEMBL7402731 0.86 CASP1 (0.57) CASP1CASP7HSD17B10PARP10PARP11
Acetic Acid SCHEMBL27953675 0.79 CASP1 (0.50) CASP1CASP7HSD17B10PARP10PARP11
SCHEMBL1027718 0.77 MAOA (0.61) CASP1CASP7HSD17B10PARP10PARP11
SCHEMBL7916500 0.77 MAOA (0.59) CASP1CASP7HSD17B10PARP10PARP11
SCHEMBL7435588 0.74 METAP1 (0.60) PARP10PARP11SRD5A1METAP1MAOB
SCHEMBL1747435 0.74 HSD17B1 (0.69) CASP1CASP7HSD17B10PARP10PARP11
SCHEMBL19422232 0.73 PARP10 (0.55) PARP10PARP11SRD5A1METAP1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0820455-B1 5H, 10H-IMIDAZO [1,2-a]INDENO [1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES AVENTIS PHARMA SA (FR) 2001-10-31 EP disclosed
US-6057454-A USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS RHONE-POULENC RORER S.A. (FR) 2000-05-02 US disclosed
US-5902803-A 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives RHONE-POULENC RORER S.A. (FR) 1999-05-11 US disclosed
EP-0820455-A1 5H, 10H-IMIDAZO [1,2-a]INDENO [1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES Aventis Pharma S.A. (FR) 1998-01-28 EP disclosed
WO-1996031511-A1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES RHONE-POULENC RORER S.A. (FR) 1996-10-10 WO disclosed