Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847249 | 0.70 | FGFR1 (0.39) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL3972648 | 0.69 | FGFR4 (0.57) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL7855674 | 0.67 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL3975789 | 0.61 | FGFR4 (0.56) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL21166429 | 0.60 | FGFR4 (0.57) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL29545927 | 0.59 | FGFR4 (0.65) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL3970204 | 0.59 | FGFR4 (0.59) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL7478752 | 0.56 | KCNMA1 (0.39) | JAK2KCNMA1MEN1ALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL7483308 | 0.55 | KCNMA1 (0.38) | JAK2KCNMA1MEN1ALDH1A1PKM | |
| SCHEMBL7478486 | 0.52 | KMT2A (0.47) | MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | claimed |