Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855274 | 0.79 | FGFR1 (0.35) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL3975643 | 0.74 | FGFR1 (0.49) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL3968638 | 0.73 | FGFR4 (0.53) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL7844860 | 0.70 | FGFR1 (0.36) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL7849122 | 0.68 | GAA (0.39) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL3970490 | 0.64 | FGFR1 (0.45) | FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL7855674 | 0.64 | ALDH1A1 (0.31) | — | |
| SCHEMBL3975154 | 0.63 | FGFR4 (0.49) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL3967533 | 0.63 | FGFR4 (0.53) | FGFR1FGFR2FGFR3KDRFGFR4 | |
| SCHEMBL3970864 | 0.62 | FGFR1 (0.49) | FGFR1FGFR2FGFR3KDRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | claimed |