Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844876 | 0.89 | IL1B (0.42) | IL1BALDH1A1 | |
| SCHEMBL7846009 | 0.83 | HDAC1 (0.37) | ALDH1A1 | |
| SCHEMBL7835032 | 0.81 | CNR1 (0.36) | — | |
| SCHEMBL7505185 | 0.79 | — | — | |
| SCHEMBL1023079 | 0.75 | IL1B (0.63) | IL1BP2RX7 | |
| SCHEMBL4720108 | 0.75 | PTGDR2 (0.37) | IL1B | |
| SCHEMBL1020688 | 0.73 | IL1B (0.55) | IL1BP2RX7 | |
| SCHEMBL27998897 | 0.73 | NOTUM (0.51) | IL1BALDH1A1P2RX7 | |
| SCHEMBL6485465 | 0.71 | ADRA2A (0.47) | IL1BP2RX7 | |
| SCHEMBL7846010 | 0.71 | ALDH1A1 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-B1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 2001-10-04 | — | — | EP | disclosed |
| US-5654305-A | TREATING PLATELET ACTIVATING FACTOR MEDIATED DISORDERS | ABBOTT LABORATORIES (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1996033196-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-10-24 | — | — | WO | disclosed |