SCHEMBL7845170

SCHEMBL7845170

Cc1ccc[c]c1-c1ccncn1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.34
MAPK9 P45984 2/20 0.32
MAPK13 O15264 1/20 0.32
RAF1 P04049 1/20 0.32
MAPK12 P53778 1/20 0.32
MAPK11 Q15759 1/20 0.32
MAPK14 Q16539 1/20 0.32
CYP3A4 P08684 2/20 0.32
HSP90AA1 P07900 1/20 0.31
LATS1 O95835 1/20 0.31
LATS2 Q9NRM7 1/20 0.31
GRM5 P41594 1/20 0.31
GSK3B P49841 1/20 0.31
LMNA P02545 1/20 0.30
CYP1A2 P05177 1/20 0.30
MAPT P10636 1/20 0.30
CYP2C19 P33261 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
CCNT1 O60563 1/20 0.30
CCNA2 P20248 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7498707 0.79 MAPK9 (0.35) CYP2D6MAPK9MAPK13RAF1MAPK12
SCHEMBL16720171 0.79 CASP6 (0.33) CYP2D6MAPK9MAPK13RAF1MAPK12
SCHEMBL4063012 0.79 KDM4E (0.46) HSP90AA1GSK3BLMNACYP1A2MAPT
SCHEMBL7852621 0.74 MAPT (0.39) MAPK13MAPK12MAPK11MAPK14GSK3B
SCHEMBL2884608 0.72 ACHE (0.42) CYP3A4CYP1A2TDP1
SCHEMBL1853430 0.72 NOS3 (0.39) CYP3A4HSP90AA1CYP1A2MAPTCYP2C19
SCHEMBL30142137 0.71 CYP1A2 (0.50) CYP2D6CYP3A4LMNACYP1A2MAPT
SCHEMBL7505751 0.71 CYP1A2 (0.50) CYP2D6CYP3A4LMNACYP1A2MAPT
SCHEMBL712064 0.69 MAPK14 (0.37) CYP2D6MAPK9MAPK13RAF1MAPK12
SCHEMBL21742568 0.68 CYP1A2 (0.47) CYP2D6CYP3A4LMNACYP1A2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144403-A1 SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS G.D. SEARLE & CO. (US) 2001-10-17 EP disclosed
WO-2000031063-A1 SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS G.D. SEARLE & CO. (US) 2000-06-02 WO disclosed