Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7498707 | 0.79 | MAPK9 (0.35) | BRAFMAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL7845170 | 0.79 | CYP2D6 (0.34) | CYP3A4MAPK13RAF1MAPK9MAPK12 | |
| SCHEMBL16720807 | 0.79 | KDM4E (0.46) | CYP3A4HSP90AA1KDM4ENPC1CA12 | |
| SCHEMBL16720178 | 0.74 | QDPR (0.44) | CYP3A4KDM4ENPC1CA12GMNN | |
| SCHEMBL16719473 | 0.72 | CYP19A1 (0.38) | CASP6CYP3A4KDM4ENPC1CA12 | |
| SCHEMBL1445131 | 0.71 | CASP6 (0.45) | CASP6ALDH1A1HPGDHSD17B10 | |
| SCHEMBL30531925 | 0.71 | CASP6 (0.45) | CASP6ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29464574 | 0.69 | KDM4E (0.42) | CASP6BRAFMAPK13RAF1MAPK9 | |
| SCHEMBL27576051 | 0.69 | CASP6 (0.44) | CASP6BRAFMAPK9MAPK14HSP90AA1 | |
| SCHEMBL16719718 | 0.69 | ATM (0.39) | CYP3A4KDM4ENPC1CA12GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068758-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | The Wistar Institute Of Anatomy And Biology (US) | 2016-09-21 | — | — | EP | disclosed |
| WO-2015073864-A1 | EBNA1 INHIBITORS AND THEIR METHOD OF USE | THE WISAR INSTITUTE OF ANATOMY AND BIOLOGY (US) | 2015-05-21 | — | — | WO | disclosed |