Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846392 | 0.77 | ADORA2A (0.55) | POLBADORA2AADORA1SMN1; SMN2NPC1 | |
| SCHEMBL7843906 | 0.76 | MAPT (0.46) | POLBNPC1RAB9ANHERF1MAPT | |
| SCHEMBL6698829 | 0.73 | MAPT (0.58) | POLBMAPTTP53MEN1KMT2A | |
| SCHEMBL7834823 | 0.72 | NHERF1 (0.60) | POLBADORA2AADORA1SMN1; SMN2NPC1 | |
| SCHEMBL6818435 | 0.71 | POLB (0.67) | POLBADORA2AADORA1SMN1; SMN2NPC1 | |
| SCHEMBL6225747 | 0.71 | ADORA2A (0.60) | POLBADORA2AADORA1SMN1; SMN2NPC1 | |
| SCHEMBL7845700 | 0.71 | NHERF1 (0.61) | POLBADORA2AADORA1SMN1; SMN2NPC1 | |
| SCHEMBL6230550 | 0.71 | NHERF1 (0.68) | POLBADORA2AADORA1SMN1; SMN2NHERF1 | |
| SCHEMBL6201470 | 0.71 | ADORA2A (0.60) | POLBADORA2AADORA1SMN1; SMN2NPC1 | |
| SCHEMBL7842334 | 0.71 | NHERF1 (0.58) | POLBADORA2AADORA1SMN1; SMN2NHERF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140850-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040561-A1 | QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |