Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837396 | 0.91 | CYP1A2 (0.36) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7848483 | 0.86 | LMNA (0.37) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7837573 | 0.85 | ENPP1 (0.33) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7848425 | 0.84 | CNR2 (0.33) | KMT2ACNR1MEN1 | |
| SCHEMBL7848445 | 0.81 | SLC10A2 (0.35) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7838190 | 0.78 | LMNA (0.41) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7837753 | 0.77 | CYP19A1 (0.31) | KMT2AF2HPGDCYP19A1MAPK1 | |
| SCHEMBL7846309 | 0.76 | CYP1A2 (0.40) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7837399 | 0.75 | NR1I2 (0.34) | HPGDMAPTALDH1A1TDP1 | |
| SCHEMBL7845064 | 0.74 | ALDH1A1 (0.37) | KMT2AHPGDCYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |