Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | SLC10A2 | Q12908 | 3/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846525 | 0.87 | CNR2 (0.40) | CNR2KEAP1NFE2L2LMNAMEN1 | |
| SCHEMBL7848425 | 0.86 | CNR2 (0.33) | CNR2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL7837755 | 0.85 | CNR2 (0.35) | CNR2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL7837233 | 0.82 | MEN1 (0.35) | CNR2LMNAMEN1KMT2ACALM1 | |
| SCHEMBL7848483 | 0.81 | LMNA (0.37) | LMNAKMT2ACNR1SLC10A2CYP1A2 | |
| SCHEMBL6200975 | 0.77 | CNR2 (0.33) | CNR2KEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL7846237 | 0.77 | APP (0.34) | CNR2LMNAMEN1KMT2ACNR1 | |
| SCHEMBL7845257 | 0.76 | CNR1 (0.37) | CNR2KEAP1NFE2L2LMNAMEN1 | |
| SCHEMBL7846899 | 0.76 | CNR2 (0.38) | CNR2KEAP1NFE2L2LMNAMEN1 | |
| SCHEMBL7846766 | 0.75 | CNR2 (0.40) | CNR2KEAP1NFE2L2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |