Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837216 | 0.89 | CNR1 (0.34) | SMN1; SMN2LMNAHTTCNR2ALDH1A1 | |
| SCHEMBL7837233 | 0.86 | MEN1 (0.35) | APPSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL7837755 | 0.83 | CNR2 (0.35) | APPMEN1KMT2ACNR2CTSK | |
| SCHEMBL6200975 | 0.83 | CNR2 (0.33) | APPMEN1KMT2ACNR2CTSK | |
| SCHEMBL7845578 | 0.81 | ACHE (0.31) | SMN1; SMN2MEN1KMT2ALMNAHTT | |
| SCHEMBL7845064 | 0.81 | ALDH1A1 (0.37) | SMN1; SMN2MEN1KMT2ALMNAHTT | |
| SCHEMBL7846110 | 0.77 | CNR2 (0.37) | APPMEN1KMT2ALMNACNR2 | |
| SCHEMBL7846693 | 0.75 | LIMK1 (0.33) | SMN1; SMN2MEN1KMT2ALMNAHTT | |
| SCHEMBL7846525 | 0.75 | CNR2 (0.40) | MEN1KMT2ALMNACNR2ALDH1A1 | |
| SCHEMBL6202014 | 0.74 | SLC10A2 (0.33) | APPMEN1KMT2ACNR2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |