Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846493 | 0.88 | ALDH1A1 (0.38) | ALDH1A1PKMPOLBL3MBTL3MEN1 | |
| SCHEMBL7845066 | 0.82 | CYP1A2 (0.36) | ALDH1A1POLBMEN1KMT2ALMNA | |
| SCHEMBL7845581 | 0.81 | ALDH1A1 (0.34) | ALDH1A1PKMPOLBL3MBTL3MEN1 | |
| SCHEMBL7846237 | 0.77 | APP (0.34) | ALDH1A1MEN1KMT2ALMNAHTT | |
| SCHEMBL7837233 | 0.73 | MEN1 (0.35) | ALDH1A1MEN1KMT2ALMNAHTT | |
| SCHEMBL7846899 | 0.72 | CNR2 (0.38) | MEN1KMT2ALMNACTSKCNR2 | |
| SCHEMBL6200975 | 0.72 | CNR2 (0.33) | ALDH1A1MEN1KMT2ACTSKMAPK1 | |
| SCHEMBL7837755 | 0.72 | CNR2 (0.35) | MEN1KMT2ACTSKCNR2 | |
| SCHEMBL7848540 | 0.71 | TBXA2R (0.37) | ALDH1A1POLBMEN1KMT2ALMNA | |
| SCHEMBL7846879 | 0.71 | CA1 (0.38) | ALDH1A1POLBMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |