Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 7/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CDC25C | P30307 | 1/20 | 0.35 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846879 | 0.91 | CA1 (0.38) | TBXA2RCA1CA2CYP1A2CYP3A4 | |
| SCHEMBL7845066 | 0.89 | CYP1A2 (0.36) | TBXA2RCA1CA2CYP1A2CYP3A4 | |
| SCHEMBL7837576 | 0.83 | TBXA2R (0.32) | TBXA2RCA1CA2CYP1A2CYP3A4 | |
| SCHEMBL7845061 | 0.80 | BAZ1A (0.36) | TBXA2RCYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL7849223 | 0.79 | SLC10A2 (0.35) | TBXA2RCYP1A2CYP2C19KMT2AALDH1A1 | |
| SCHEMBL7846878 | 0.77 | CYP1A2 (0.36) | TBXA2RCYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL7850479 | 0.77 | NPSR1 (0.36) | TBXA2RCYP1A2CYP2C19ALDH1A1CDC25C | |
| SCHEMBL7845064 | 0.76 | ALDH1A1 (0.37) | CYP1A2CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL7848868 | 0.75 | SMN1; SMN2 (0.33) | CA1CYP1A2CYP2C19ALDH1A1CDC25C | |
| SCHEMBL7838193 | 0.75 | ALDH1A1 (0.41) | CYP1A2CYP2C19KMT2AALDH1A1CDC25C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155007-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. Searle LLC (US) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047568-A2 | 1,2-BENZOTHIAZEPINES FOR THE TREATMENT OF HYPERLIPIDEMIC DISEASES | G.D. SEARLE LLC (US) | 2000-08-17 | — | — | WO | disclosed |