Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.41 |
| ▸ | CASR | P41180 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91362 | 0.84 | REN (0.43) | RENL3MBTL1POLBCNR1CNR2 | |
| SCHEMBL78487 | 0.82 | REN (0.52) | RENCASRL3MBTL1CNR1CNR2 | |
| SCHEMBL78476 | 0.73 | ICMT (0.42) | CNR1CNR2 | |
| SCHEMBL78479 | 0.71 | HTR7 (0.53) | REN | |
| SCHEMBL78153 | 0.68 | REN (0.55) | RENCASR | |
| SCHEMBL78417 | 0.67 | CNR2 (0.53) | L3MBTL1CNR1CNR2 | |
| SCHEMBL16471683 | 0.67 | REN (0.51) | RENCNR1CNR2 | |
| SCHEMBL12523924 | 0.66 | REN (0.52) | RENCNR1CNR2 | |
| SCHEMBL4602445 | 0.66 | ICMT (0.44) | RENCNR1CNR2 | |
| SCHEMBL78865 | 0.66 | ICMT (0.42) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |