Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375397 | 0.81 | KDM4E (0.52) | MAPTKDM4EHTR6HTR1A | |
| SCHEMBL7370973 | 0.80 | GABRP (0.49) | HTR6HTR1A | |
| SCHEMBL6212815 | 0.78 | HTR1D (0.62) | MAPTKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL2347633 | 0.78 | PDE10A (0.54) | PDE10AMAPTKDM4EBRD4ALDH1A1 | |
| SCHEMBL8618496 | 0.77 | CYP1A2 (0.63) | MAPTKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL8120106 | 0.76 | HTR1D (0.49) | KDM4EBRD4ALDH1A1POLBCREBBP | |
| SCHEMBL27337232 | 0.76 | KDM4E (0.43) | MAPTKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL12127418 | 0.76 | KDM4E (0.49) | MAPTKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL30567991 | 0.76 | OPRM1 (0.53) | MAPTKDM4EBRD4ALDH1A1POLB | |
| SCHEMBL4674153 | 0.76 | HSD11B1 (0.60) | KDM4EBRD4ALDH1A1POLBCREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |