Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752176 | 0.83 | KEAP1 (0.43) | ALDH1A1KEAP1NFE2L2MAPK1 | |
| SCHEMBL7851053 | 0.81 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1KDM4EHPGDKMT2A | |
| SCHEMBL2334379 | 0.78 | KEAP1 (0.56) | ALDH1A1L3MBTL1KDM4EPOLBKEAP1 | |
| SCHEMBL6752244 | 0.77 | HTR2A (0.36) | KDM4EKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6750723 | 0.76 | TAAR1 (0.46) | ALDH1A1MAPK1 | |
| SCHEMBL182586 | 0.75 | ALDH1A1 (0.40) | ALDH1A1KDM4EPOLBHPGDKMT2A | |
| SCHEMBL6745866 | 0.74 | HDAC4 (0.36) | ALDH1A1KMT2A | |
| SCHEMBL7849449 | 0.73 | SMN1; SMN2 (0.51) | ALDH1A1POLBKEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7410161 | 0.73 | CA12 (0.51) | ALDH1A1L3MBTL1KDM4EMAPK1KMT2A | |
| SCHEMBL15705773 | 0.72 | MMP1 (0.54) | ALDH1A1KDM4EKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018734-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-04-06 | — | — | WO | disclosed |