Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 8/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839475 | 0.86 | KEAP1 (0.39) | SMN1; SMN2KEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL697566 | 0.76 | SMN1; SMN2 (0.73) | SMN1; SMN2KEAP1NFE2L2ALDH1A1MMP2 | |
| SCHEMBL7849283 | 0.75 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL1043536 | 0.74 | KMT2A (0.38) | SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL7849396 | 0.73 | ALDH1A1 (0.46) | SMN1; SMN2KEAP1NFE2L2ALDH1A1POLB | |
| SCHEMBL16295402 | 0.72 | NNMT (0.33) | — | |
| SCHEMBL8317551 | 0.72 | KEAP1 (0.30) | KEAP1 | |
| SCHEMBL10698791 | 0.72 | LMNA (0.52) | ALDH1A1POLB | |
| SCHEMBL4934333 | 0.71 | SMN1; SMN2 (0.70) | SMN1; SMN2KEAP1NFE2L2ALDH1A1MMP2 | |
| SCHEMBL16294301 | 0.71 | RAB9A (0.36) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | Boehringer Ingelheim Pharma KG (DE) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018734-A1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-04-06 | — | — | WO | disclosed |