⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8373088 | 0.82 | LMNA (0.32) | — | |
| SCHEMBL7840152 | 0.73 | OPRM1 (0.30) | — | |
| SCHEMBL26044409 | 0.69 | — | — | |
| SCHEMBL25712254 | 0.69 | — | — | |
| SCHEMBL10129912 | 0.69 | — | — | |
| SCHEMBL7858099 | 0.68 | MEN1 (0.31) | — | |
| SCHEMBL9963382 | 0.67 | LMNA (0.35) | — | |
| SCHEMBL761435 | 0.67 | LMNA (0.35) | — | |
| SCHEMBL18975339 | 0.67 | — | — | |
| SCHEMBL22098680 | 0.66 | HSD11B1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998958-B2 | Substituted N-arylsulfonylheterocyclic amines as gamma-secretase inhibitors | SCHERING CORPORATION (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100093695-A1 | Substituted N-Arylsulfonylheterocyclic Amines As Gamma-Secretase Inhibitors | SCHERING CORP. | 2010-04-15 | — | — | US | disclosed |