Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8137442 | 1.00 | HTR1A (0.55) | HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL7852201 | 0.83 | HSD11B1 (0.47) | HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL8137953 | 0.83 | HSD11B1 (0.47) | HTR1ADRD2 | |
| SCHEMBL9458475 | 0.71 | HTR1A (0.62) | HTR1ADRD2 | |
| SCHEMBL9458466 | 0.71 | HTR1A (0.62) | HTR1ADRD2 | |
| SCHEMBL8808944 | 0.71 | HTR1A (1.00) | HTR1ADRD2 | |
| SCHEMBL9458462 | 0.71 | HTR1A (0.62) | HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL9458335 | 0.70 | HTR1A (0.61) | HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL9458338 | 0.70 | HTR1A (0.61) | HTR1ADRD2 | |
| SCHEMBL8139159 | 0.67 | HTR1A (0.49) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805812-B1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |
| WO-1996022991-A1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |