Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | MT-CO2 | P00403 | 3/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30295791 | 1.00 | PTGS2 (0.50) | PTGS2PTGS1CA1CA2MT-CO2 | |
| SCHEMBL30296173 | 0.79 | CA4 (0.36) | PTGS2PTGS1CA1CA2MT-CO2 | |
| SCHEMBL27968617 | 0.79 | CA2 (0.46) | PTGS2PTGS1CA1CA2MT-CO2 | |
| SCHEMBL30844560 | 0.78 | NR3C1 (0.44) | PTGS2MT-CO2ALDH1A1EDNRBEDNRA | |
| SCHEMBL29281009 | 0.78 | NR3C1 (0.44) | PTGS2MT-CO2ALDH1A1EDNRBEDNRA | |
| SCHEMBL7549323 | 0.78 | EDNRA (0.48) | PTGS2PTGS1CA1CA2MT-CO2 | |
| SCHEMBL6820502 | 0.78 | PTGS2 (0.62) | PTGS2PTGS1CA1CA2MT-CO2 | |
| SCHEMBL30296014 | 0.77 | EDNRB (0.36) | PTGS2PTGS1CA1CA2MT-CO2 | |
| SCHEMBL30295930 | 0.77 | CA1 (0.34) | PTGS2PTGS1CA1CA2MT-CO2 | |
| SCHEMBL7850630 | 0.76 | CA2 (0.44) | PTGS2PTGS1CA1CA2MT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1094816-A4 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | claimed |
| EP-1094816-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-05-02 | — | — | EP | claimed |
| WO-2000001389-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-01-13 | — | — | WO | claimed |