Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.52 |
| ▸ | EDNRB | P24530 | 12/20 | 0.52 |
| ▸ | DHPS | P49366 | 2/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696683 | 0.93 | EDNRA (0.56) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7696685 | 0.86 | EDNRA (0.57) | EDNRAEDNRBDHPS | |
| SCHEMBL7853937 | 0.84 | DHPS (0.57) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7699796 | 0.84 | EDNRA (0.52) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7851035 | 0.84 | EDNRA (0.48) | EDNRAEDNRBDHPS | |
| SCHEMBL4061140 | 0.78 | EDNRA (0.67) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7700296 | 0.77 | EDNRA (0.57) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7699797 | 0.76 | DHPS (0.56) | EDNRAEDNRBDHPS | |
| SCHEMBL4060083 | 0.76 | EDNRA (0.64) | EDNRAEDNRBDHPS | |
| SCHEMBL7850330 | 0.73 | EDNRA (0.81) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713875-B1 | Sulfonamides | HOFFMANN LA ROCHE (CH) | 2001-03-21 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |